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KMID : 0361020120550020071
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Korean Journal of Otolaryngology - Head and Neck Surgery
2012 Volume.55 No. 2 p.71 ~ p.75
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Human Papilloma Virus Positive Oropharyngeal Cancer
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Park Jung-Je
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Abstract
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Human papilloma virus (HPV) is associated with the progression of head and neck squamous cell carcinoma (HNSCC), particularly tonsils and base of tongue. HPV (+) HNSCC represent a distinct disease entity from those are implicated in carcinogen. The molecular mechanism underlying HPV tumorgenesis are appreciated, with its two major oncogens E6 and E7, inactivating p53 and Rb, respectively. However, the ideal technique for HPV determination on archival material or tissue remains uncertain. This paper reviewed the epidemiology, clinical presentation, pathogenesis, diagnosis, therapy and prevention.
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KEYWORD
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Head and neck cancer, Human papilloma virus
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